Remote Procedure Call (RPC) is a protocol for simplifying distributed computing. It allows users to call functions on remote servers, making it easier to build distributed systems. RPC uses a client-server model, converts data for sending, and uses stubs/skeletons for communication. Binding connects clients and servers, and it is able to work synchronously or asynchronously. RPC is crucial for building distributed apps and microservices, allowing smooth communication between languages and platforms.